***Local Pickup Only***


FIRST DEFENSE® TRI-SHIELD™ combines the E. coli and coronavirus
antibodies contained in FIRST DEFENSE®, with rotavirus antibody content
to produce the only product on the market with trivalent protection
against three of the leading pathogens that lead to calf scouring.
Preventing scours in newborn calves reduces the need to use treatment
antibiotics later in life. Comes in a gel tube delivery format.


  • Keep refrigerated.
  • No meat withholding.
  • Derived form 100% bovine antibodies from colostrum.
  • Administer as soon as possible after birth; does not require any colostrum withholding.
  • A single dose of First Defense provides a guaranteed level of protection, proven to reduce mortality and morbidity from 3 major causes of calf scours.

First Defense Tri-Shield-12 Single Dose/Box



    Telephone:  800-466-8235
    Order Desk:  800-466-8235
    Fax:  207-878-2117
    Website:  www.FirstDefenseCalfHealth.com
    Email:  orders@immucell.com
      Every effort has been made to ensure the accuracy of the information published. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the USA product label or package insert.



    Developer of First Defense®

    Bovine Rotavirus-Coronavirus-Escherichia Coli Antibody, Bovine Origin

    One Dose Per Calf • Store Refrigerated



    K99+ E. coli

    TRI-SHIELD FIRST DEFENSE® has been shown to be effective for passive immunity against K99+ E. coli, bovine coronavirus and bovine rotavirus when administered within 12 hours of birth.

    Specifically, TRI-SHIELD FIRST DEFENSE® aids in the reduction of:

    • Mortality and morbidity from scours caused by K99+ E. coli and bovine coronavirus.

    While also reducing:

    • Severity and duration of scours caused by bovine rotavirus.

    DIRECTIONS: Do not delay colostrum. For best results, TRI-SHIELD FIRST DEFENSE® gel should be administered to calves orally, within 12 hours after birth. Remove the tube cap, placing the tip at the back of the throat, toward the cheek pocket. Initiate the plunger and squeeze the entire tube contents into the calf’s mouth, ensuring the calf swallows all of the gel.

    PRECAUTIONS: Store refrigerated (35-46°F, 2-8°C). Do not split dose between multiple calves. Use entire contents when first opened. Blue dye is non-digestible serving as a tracker through the system to ensure calf received treatment. First fecal stool after administration will be blue-green in color. For use in animals only. Do not mix with other products, except as specified on the label. Do not freeze. Preservative: Thimerosal

    • Vea el recuadro para obtener instrucciones en español

    • Voir l’encadré pour les instructions en français

    U.S. Veterinary License No. 327

    PCN 3625.R2



    Manufactured by ImmuCell Corporation, 56 Evergreen Drive, Portland, ME 04103

    Rev 3

    CPN: 1120011.5